While the long-running hit for The CW will be adding some new names to its cast when it returns midseason, the biggest news revolves around its most recognizable name. Isaiah Washington will be departing the show as a series regular for season 5. It is not known how his character will be written out and if he’ll stay in a recurring role but his days as a full-timer are done (for now).

The Arrow-verse always has a revolving door of comings-and-goings given its nature of being a super-hero series and this season will be no different. In addition to Katie Cassidy returning to full-time status as the evil version of her long-time character and supporting stars Juliana Harkavy (Black Canary) and Rick Gonzelaz (Wild Dog) getting a similar status upgrade, fans will see a few new faces. Fringe and 12 Monkeys star Kirk Acevdeo will recur as Richard Dragon, a new opponent for team Green and Lost star Michael Emerson will also recur but details are still being kept secret on his role. Meanwhile GLOW’s Sydelle Noel will pop up in Star City as a FBI agent looking into the connection between Oliver Queen and alter-ego Green Arrow

While the idea of a Blacklist spin-off was fun, the execution wasn’t anything special. Now with Redemption being one-and-done, fans were curious what that meant for original series regular Ryan Eggold who had switched shows. As foreshadowed in the season finale, Eggold’s character Tom Keane will be back and in a major way, however last season’s recurring guest star Enrique Murciano will not return after his character wasn't well received.with viewers.

Dick Wolf’s “One Chicago” brand had one of its biggest off-seasons yet with a number of real-life plot twists that took the action off the screen. The biggest news is the exit of Sophia Bush from PD which came as a shock to fans. The beloved character (and actress) is stepping away from the show which paves the way for last season’s recurring guest Tracy Spiradakos to be upped to full-time. The Intelligence family will also welcome back one of its own as Jon Seda returns following the cancellation of spin-off Chicago Justice. Mykelti Williamson is also slated for a return following his introduction last season as the old (and sketchy) partner of Hank Voight (series lead Jason Beghe). Lastly, former Justice lead Philip Westchester will have a new home in the fall – he’ll join Law & Order: Special Victims Unit.

Criminal Minds continues to thrive despite a revolving door situation among its ensemble. Following the cancellation of spin-off Beyond Borders, CBS will bring Daniel Henney over to the mothership as a series regular. He’ll replace Damon Gupta who leaves the show after one season.

ABC’s Designated Survivor is a good show but still needs to find its identity. In season two the Kiefer Sutherland-fronted drama will look to do that by expanding its cast. Zoe McLellan (NCIS: New Orleans) and Paulo Costanzo (Royal Pains) will both join the ensemble as new members of the Kirkman administration while Ben Lawson (The Deep End) will come on as a MI6 operative that crosses paths with Maggie Q’s character Agent Hannah Wells. Last season’s recurring guest-star Virginia Madsen will depart the series as set up towards the end of season one.

Arrow isn’t the only one of the CW’s shows to reset the playing field in the fall as The Flash has a few casting moves of its own in mind. Cult favorite Danny Trejo is the biggest name to join the show’s guest-star ranks as the father of bounty hunter Gypsy. Meanwhile iconic DC character Ralph Dibgy (aka The Elongated Man) will make his first appearance as played by soap star Hartley Sawyer as he helps team Red battle its first non-speedster big-bad, The Thinker, played by Neil Sandilands (The 100). On the other side of the coin, Tom Felton, who had played Flash alley Julian Albert will not return as a series regular in season 4.

Now entering its 14th season, Grey’s Anatomy continues to pump in and out cast members and this season is no different. Chief among the changes, the show will finally give audiences a pay-off for the long-running storyline revolving around Owen Hunt’s (Kevin McKidd) presumed dead sister with Abigail Spencer (Timeless) taking over the part from Bridger Regan (who had to drop out due to scheduling conflicts). Meanwhile Andrew DuLuca (Giacomo Gianniotti) will also see his sister join the halls of Grey Sloan Memorial as Satisfaction star Stefania Spampinato comes on board. Former cast member Kim Raver will also reprise he role as Dr. Teddy Altman while Jerrika Hinton and Marika Dominczyk will exit.

Hawaii Five-0 may have had the biggest casting changes of any show over the summer as original cast members Daniel Dae Kim and Grace Park announced they would not be returning to the series. The pair left over a salary dispute and will be replaced by two new cast members (Meaghan Rath, Beulah Koale) and the promotion of another (Ian Anthony Dale) to full-time. Dale’s increased presence is a bit ironic given his character and Park’s character were married.

Next to Hawaii Five-0, it was Kevin James’ Kevin Can Wait that made the biggest casting news and this one was just as big of a headache for network executives. After Leah Remini’s two-episode guest shot at the close of season one it was announced she would join the show full time in season two – yet not long after it was announced series co-lead Erin Hayes would exit. CBS then made headlines over the summer when it announced Hayes’ character would be killed off as the show changes its narrative to focus on James returning to the workforce and being a single dad. This is supposed to be a comedy right?

With NCIS losing core characters in the last few years producers have been working hard to ensure the overall team’s cohesion stays intact. Last year the show added three new series regulars but only two are returning as Jennifer Esposito will leave the procedural. The show then will add Maria Bello (Prime Suspect. Goliath) to the mix as a replacement playing a forensic psychologist which should shake up the team dynamic in an interesting way. Meanwhile the show’s Los Angeles counterparts will also see a big change as Nia Long joins the cast as the new executive assistant director following the exit of Miguel Ferrer who sadly passed away last season.

The long-running fantasy series will reset itself this season with all but three of the show’s original ensemble exiting the fold. Sticking around will be Lana Parrilla (Regina/Wicked Witch), Robert Carlyle (Mr. Gold/Rumpelstiltskin) and Colin O'Donoghue (Captain Hook) who will be joined by newcomers Andrew J. West, Alison Fernandez, Dania Ramirez and Gabrielle Anwar. Former lead Jennifer Morrison will guest star in the season premiere to wrap up her storyline, but may potentially return down the line (as could other original cast members).

Like Once Upon A Time, Quantico will re-shuffle its pieces for season 3 with only Priyanka Chopra, Jake McLaughlin and Johanna Braddy remaining from the original cast. However last season’s biggest addition Blair Underwood will also return along with Russell Tovey who had previously recurred. The series will then add Oscar winner Marlee Maitlin to its full-time cast.

Hopefully gone for good – the flashback sequences that nearly doomed the show early on.

The biggest casting news around Riverdale is the one that won’t be addressed until the season premiere as fans await the fate of Archie’s dad (played by Luke Perry) who was shot in the show’s finale. Veronica’s (Camila Mendes) dad on the other hand will finally make his first appearance after spending the first season off-screen in jail and he’ll be played by Pitch’s Mark Consuelos. The show has also upped Skeet Ulrich and Casey Cott to full-time regulars with Charles Melton taking over the role of Reggie from Ross Butler who is committed to the second season of Thirteen Reasons Why.

As the Shonda Rhimes thriller enters its swan-song season, recurring star George Newbern is finally getting the bump to series regular following his expanded role last year. The show will also bring on Homeland’s Shaun Toub and Suicide Squad’s Jay Hernandez as the newest members of the team that is now being managed by former Olivia Pope protégé Quinn Perkins (Katie Lowes).